PÉPTIDOS ANTIMICROBIANOS: UN PANORAMA GENERAL CONTRA LA TRICOMONIASIS

Sofia Fonseca Yepez

Resumen


Resumen

El presente escrito muestra al parásito Trichomonas vaginalis como el agente causal de la tricomoniasis, enfermedad de transmisión sexual y como ésta se debería de considerar de gran importancia para los sistemas de salud pública. La tricomoniasis afecta tanto a mujeres como a hombres, sin embargo, frecuentemente es asintomática. Actualmente, el único tratamiento aprobado consiste en fármacos de la familia de los 5-nitroimidazoles; además, la selección de cepas de T. vaginalis resistentes a estos compuestos y los efectos secundarios adversos que producen, resaltan la necesidad de contar con alternativas de tratamiento. Ante esta problemática, el presente artículo también se plantea un panorama en torno al estudio de los péptidos antimicrobianos, los cuales podrían ser una estrategia prometedora para controlar a diferentes microorganismos patógenos. No obstante, aún son pocos los estudios del efecto microbicida de los péptidos contra T. vaginalis, por lo que enfatizamos su utilización como un área de oportunidad para su control.

 

Palabras clave: Péptidos antimicrobianos; tricomoniasis; resistencia microbicida.

 

“ANTIMICROBIAL PEPTIDES: AN OVERVIEW AGAINST TRICOMONIASIS”

Abstract

This paper highlights the parasite Trichomonas vaginalis as the etiological agent of trichomoniasis, a sexually transmitted disease, and how this disease should be of a great importance to public health systems. Trichomoniasis affects both women and men, however this infection often remains asymptomatic. Currently, the only treatment approved is 5-nitroimidazole derivatives and the emergence of T. vaginalis-resistant strains besides its side effects emphasizes the need for treatment alternatives. This minireview addresses this problem and provides an overview of recent research on antimicrobial peptides, which seems to be a promising strategy to control pathogens. However, there are still few studies on the microbicidal effects of these bioactive compounds against T. vaginalis, so we attract attention to antimicrobial peptides used for future therapeutic control of trichomoniasis.

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Referencias


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